In many cases, yes. A hand-painted mural has no seams, does not peel at the edges and can be adapted exactly to the architecture of the room. It is durable, can help to hide small imperfections in the wall and can be retouched or changed later if needed.
Wallpaper is a good quick solution for simple patterns, but if you want something unique, long-lasting and tailored to your space, a mural is usually the more practical choice in the long run.